Human insulin (recombinant DNA) and purified porcine insulin were compared in healthy men. Intravenous insulin tolerance tests showed identical effects on plasma glucose when a bolus of 0.1 U/kg was injected. Following human insulin, hypokalemia and epinephrine secretion were significantly less pronounced. The differences in serum potassium concentrations are caused by a lower epinephrine response to hypoglycemia induced by human insulin in comparison to purified porcine insulin.
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